In the unsteady and interdependent modern market, the concept of supply chain resilience became one of the key strategies. The current study examines, quantitatively, the connection between the leadership qualities and the crisis preparedness particularly linked with the role played by the human-centric leadership and its impact on the performance of supply chains under the disruptions. A group of middle to higher rank supply chain managers of varying industries was used to explore how the top leadership features of emotional intelligence, adaptability, strategic vision, decisiveness, and communication affect the resilience of the organization. Structural equation modeling and correlational analysis was used to determine characteristics that were most associated with crisis preparedness. Findings show that emotional intelligence and strategic vision go well together as predictors of resilience, through the mediation of organizational culture and psychological safety. The study paves way in understanding leadership theory, crisis management, and operational strategy through provision of empirical data that will aid in the inclusion of the human factor when planning and training on resilience.