The foundation the application of state-of-the-art scientific methods to address environmental issues that occur during laboratory experiments. Our focus is on the medicinal chemistry processes used in labs to prepare APIs. This article offers a guide to making reactions more environmentally friendly and suggests alternative, environmentally friendly responses that might replace the tactics used by businesses and universities. Also included is an easy-to-follow process for making azide [1,2-a] pyridines when left alone using a KI/TBHP catalytic system, without the need for solvents or metals. and chapter 5 Here, we examine some methods that medicinal chemists can employ to improve both the environment and human health: boosting yields while reducing or eliminating pollution.