Interactions between drugs, foods, plants, or illnesses are known as drug interactions (DIs). These possibilities may be better understood by looking at the patient's medical history, of the medicine, taking into consideration the patient's pharmacodynamics and pharmacokinetics any other illnesses going on at the same time. When used as prescribed, medicine improves health and alleviates symptoms. However, if a drug doesn't combine well with other substances you consume, such as another medicine, certain foods, or alcohol, it can cause unwanted side effects. In order to adhere to ethical standards, animal studies were conducted to investigate two drug combinations for which no definitive information was available when monitoring adverse drug reactions in this investigation.