This qualitative study explores the relationship between personality traits and health perceptions among college students through semi-structured interviews. By examining the influences of traits such as neuroticism, conscientiousness, extraversion, and openness, the study identifies key themes that demonstrate how these personality characteristics affect students' health perceptions and behaviours. The analysis reveals that neuroticism tends to be associated with negative health perceptions, while conscientiousness and extraversion generally contribute to more positive health behaviours and perceptions. Openness influences proactive health engagement by fostering greater information-seeking. These findings suggest that personality-tailored interventions could effectively enhance health perceptions and outcomes in college settings. The study contributes to a deeper understanding of the psychological factors that influence health perceptions and offers practical insights for designing targeted health promotion strategies in educational environments.